Morphological and Morphmetric Studies on Embryo Development in Camphor Treated Pregnant Rats
Keywords:Camphor; Pregnant rats; Embryos
Camphor has long been used in dead bodies wash in Saudi Arabia. Experiments were conducted to study the effect of camphor on SpragueDawley rats and embryos. Pregnant rats (n = 36) were divided into 4 groups (n = 9); 3 groups were given intraperitoneal injection by different doses of water camphor solution (5, 10 and 20 mg camphor/kg body weight); control group was given the same doses of distilled water. All groups were kept in constant room temperature (22o± 2oC), and in a 12 h light/12 h dark photoperiod. At the end of 1st, 2nd and the 3rd week of gestation, 3 animals from each group were anesthetized; their plasma and embryos were removed. The results obtained showed a significant increase in body weight of pregnant rats in week 1 of gestation for G2 (10 mg/kg), and in week 2 of gestation for G3 (20 mg/kg) compared to control. The hormonal analysis did not show significant differences with all used doses. However, a significant decrease in fetal body length and weight were recorded, increase in number of dead and incomplete growth embryos in G3 (20 mg/kg) were observed. The present study shows that camphor effects on rats embryos. Therefore, caution is recommended in its use, especially for pregnant women.
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